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pentobarbital will increase the stage or outcome of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers reduced ivosidenib plasma concentrations.Individuals stabilized on corticosteroid therapy may need dosage adjustments if barbiturates are a